188金宝博娱乐城-明升投注网 -博彩网 源码程序

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博士，教授，碩士生導(dǎo)師。曾在美國(guó)西南醫(yī)學(xué)中心、斯坦福大學(xué)諾貝爾獎(jiǎng)得主Thomas C. Südhof教授實(shí)驗(yàn)室從事博士后研究，長(zhǎng)期從事囊泡轉(zhuǎn)運(yùn)與釋放，鈣離子調(diào)節(jié)神經(jīng)遞質(zhì)釋放機(jī)制的科學(xué)研究工作。在包括Science，Neuron，PNAS，EMBO Rep，J Neurosci等國(guó)際著名期刊在內(nèi)的各類(lèi)SCI收錄期刊中發(fā)表文章20余篇。主持多項(xiàng)國(guó)家自然科學(xué)基金、湖北省自然科學(xué)基金。先后入選國(guó)家民委中青年英才計(jì)劃及湖北省優(yōu)秀青年骨干人才計(jì)劃。目前主要運(yùn)用分子/生化，遺傳學(xué)，電生理和光學(xué)等手段，在生理和病理情況下研究神經(jīng)系統(tǒng)細(xì)胞信號(hào)跨膜傳導(dǎo)的時(shí)空調(diào)節(jié)機(jī)制，研究重點(diǎn)包括神經(jīng)遞質(zhì)釋放分子機(jī)制，神經(jīng)突觸形成與調(diào)節(jié)機(jī)理，神經(jīng)網(wǎng)絡(luò)發(fā)育調(diào)控，藥物鎮(zhèn)痛機(jī)制等。研究成果為診斷、治療重大神經(jīng)性疾病提供生物學(xué)基礎(chǔ)。

近年代表性研究成果（論文、專(zhuān)著、獲獎(jiǎng)、專(zhuān)利等）

1.Xiaofei Yang*, Yea Jin Kaeser-Woo*, Zhiping P. Pang, Wei Xu, Thomas C. Südhof. Complexin Clamps Asynchronous Releaseby Blocking a Secondary Ca2+-Sensor via its Accessory a-Helix. Neuron. 2010 Dec 9:68,907-920.

2.Xiaofei Yang, Peng Cao, Thomas C. Südhof. Deconstructing Complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20777-82.

3.Xiaofei Yang#, Dongmei Hou, Wei Jiang, Chen Zhang#. Intercellular protein-protein interactions at synapses. Protein Cell.2014 Jun;5(6):420-44.(#共同通訊作者)

4.Wei Jiang, Rui Hua, Mengping Wei, Chenhong Li, Zilong Qiu, Xiaofei Yang#, Chen Zhang. An optimized method for high-titer lentivirus preparations without ultracentrifugation. Sci Rep. 2015 Sep 8;5:13875. doi: 10.1038/srep13875.(#共同通訊作者)

5.Xiaofei Yang#，Jimin Pei，Yea Jin Kaeser-Woo，Taulant Bacaj，Nick V. Grishin，Thomas C. Südhof#，Evolutionary Conservation of Complexins: From Choanoflagellates to Mice，EMBO Reports，2015，16（10）：1308-1317. (#共同通訊作者)

6.Jihong Gong; Ying Lai; Xiaohong Li; Mengxian Wang; Jeremy Leitz; Yachong Hu; Yunxiang Zhang; Ucheor B. Choi; Daniel Cipriano; Richard A. Pfuetzner; Thomas C. Südhof; XiaofeiYang# ; Axel T. Brunger#; Jiajie Diao#, C-terminal domain of mammalian complexin-1 localizes to highly curved membranes, Proc Natl Acad Sci U S A., 2016.11.22, 113(47): E7590~E7599(#共同通訊作者)

7.Shen Wang ; Ucheor B. Choi ; Jihong Gong ; Xiaoyu Yang; Yun Li; Austin L. Wang; Xiaofei Yang#; Axel T. Brunger#; Cong Ma#, Conformational Changes of Syntaxin Linker Region induced by Munc13s Ignite SNARE-Complex Assembly in Synaptic Exocytosis, The EMBO Journal, 2017.3.15, 36(6): 816~829(#共同通訊作者)

8. Wei Jiang; Mengping Wei; Mengna Liu; Yunlong Pan; Dong Cao; Xiaofei Yang#; Chen Zhang#, Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation, Journal of Neuroscience, 2017.10.11, 37(41): 9828~9843(#共同通訊作者)

9. Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang#. Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis. Front Mol Neurosci. 2018 Feb 26;11:61. (#通訊作者)

10.Su Chen, Yi Rong, Mengxue Liu, Song Cheng, Xiangming Liu, Xiaohong Li, Yi Yu, Guangzhong Yang, Xiaofei Yang#. Analgesic Effects of Triterpenoid Saponins From Stauntonia chinensis via Selective Increase in Inhibitory Synaptic Response in Mouse Cortical Neurons. Front Pharmacol. 2018 Nov 12;9:1302.(#共同通訊作者)