出生年月：1974年9月

民族：漢族

職稱(chēng)：教授，藥學(xué)博士生導(dǎo)師

學(xué)科專(zhuān)業(yè)：藥理學(xué)和生藥學(xué)

研究方向：尹世金，教授，副院長(zhǎng)，碩士生導(dǎo)師。2009年獲武漢大學(xué)微生物學(xué)專(zhuān)業(yè)博士學(xué)位，先后在美國(guó)University of Texas Health Science Center at Houston和Washington University in St Louis從事藥理學(xué)和神經(jīng)生物學(xué)博士后研究工作。主要從事離子通道藥理學(xué)研究，以疾病相關(guān)性離子通道蛋白為靶點(diǎn)，研究生物活性多肽和有機(jī)小分子在感覺(jué)過(guò)敏性反應(yīng)（痛和癢）及自身免疫性疾病發(fā)生中的作用。發(fā)現(xiàn)瞬時(shí)電位受體通道TRPV1和TRPA1介導(dǎo)類(lèi)維生素A的痛覺(jué)過(guò)敏反應(yīng)；證明人源性Beta防御素2通過(guò)直接作用于免疫細(xì)胞tlr4受體，誘導(dǎo)細(xì)胞因子釋放并作用于小鼠背根神經(jīng)節(jié)細(xì)胞TRPV1通道而致癢；闡明了Kv1.3通道介導(dǎo)蝎、蜈蚣毒素多肽和傣藥龍血竭中查爾酮類(lèi)化合物的免疫抑制作用。主持國(guó)家自然科學(xué)基金3項(xiàng)，主持和參與科技部國(guó)家重點(diǎn)研發(fā)計(jì)劃等省部級(jí)項(xiàng)目10余項(xiàng)；發(fā)表研究論文80余篇，其中包括Immunity、Nat Commun和The Journal of Clinical Investigation等自然指數(shù)收錄的SCI論文40余篇；獲國(guó)家發(fā)明專(zhuān)利4項(xiàng)；獲湖北省科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)、二等獎(jiǎng)各一項(xiàng)；獲湖北省教學(xué)成果二等獎(jiǎng)一項(xiàng)；獲民族醫(yī)藥協(xié)會(huì)科技進(jìn)步一等獎(jiǎng)一項(xiàng)。現(xiàn)任中國(guó)民族醫(yī)藥協(xié)會(huì)理事和智庫(kù)專(zhuān)家、湖北省中醫(yī)藥學(xué)會(huì)常務(wù)理事、湖北省藥學(xué)會(huì)中藥和天然藥專(zhuān)業(yè)委員會(huì)委員、湖北省毒理學(xué)會(huì)理事。獨(dú)立承擔(dān)了《生物化學(xué)》、《生物化學(xué)實(shí)驗(yàn)》、《解剖生理學(xué)實(shí)驗(yàn)》等多門(mén)課程的教學(xué)工作。

電子郵箱：[email protected]

一、主持和參與的主要省部級(jí)研究項(xiàng)目：

1、湖北省自然科學(xué)基金創(chuàng)新發(fā)展聯(lián)合基金重點(diǎn)項(xiàng)目，2024AFD262，參芪升免方對(duì)膀胱癌生長(zhǎng)抑制作用及醫(yī)院制劑研究，2024/5-2027/5、20萬(wàn)元、在研、主持。

2、國(guó)家重點(diǎn)研發(fā)計(jì)劃中醫(yī)藥現(xiàn)代化研究重點(diǎn)專(zhuān)項(xiàng)項(xiàng)目下設(shè)一級(jí)子項(xiàng)目，2019YFC1712402，經(jīng)典藏藥如意珍寶片和白脈軟膏的藥效分析與現(xiàn)代藥理研究，2019/7-2023/7、107萬(wàn)元、結(jié)題、子課題負(fù)責(zé)人

3、企事業(yè)單位委托項(xiàng)目，HZY19025，一種龍血素B衍生物的全合成及其治療類(lèi)風(fēng)濕性關(guān)節(jié)炎藥效評(píng)價(jià)，2019/08-2022/7、20萬(wàn)元、在研、主持。

4、武漢市國(guó)際科技合作計(jì)劃項(xiàng)目，2017030209020256、Kv1.3通道介導(dǎo)查爾酮類(lèi)化合物治療自身免疫疾病的機(jī)制、2017/06-2019/12、20萬(wàn)元、結(jié)題、主持。

5、湖北省技術(shù)創(chuàng)新專(zhuān)項(xiàng)(對(duì)外科技合作類(lèi))，2017AHB067、傳統(tǒng)中藥止癢分子機(jī)制的國(guó)際合作研究、2017/06-2019/12、30萬(wàn)元、在研、參與。

6、國(guó)家自然科學(xué)基金應(yīng)急管理項(xiàng)目，81641186、龍血竭中的Kv1.3阻斷劑及其自身免疫調(diào)節(jié)作用、2017/01-2017/12、10萬(wàn)元、已結(jié)題、主持。

7、湖北省技術(shù)創(chuàng)新專(zhuān)項(xiàng)重大項(xiàng)目，2016ACA138，基于天然產(chǎn)物來(lái)源的生物活性化合物庫(kù)設(shè)計(jì)生產(chǎn)及應(yīng)用開(kāi)發(fā)關(guān)鍵技術(shù)研究，2016/09-2018/12、100萬(wàn)元、已結(jié)題、參與。

8、國(guó)家自然科學(xué)基金面上項(xiàng)目，81373379、中國(guó)蜈蚣目物種多樣性調(diào)查及藥用物種轉(zhuǎn)錄組學(xué)研究、2014/01-2017/12、70萬(wàn)元、已結(jié)題、主持。

9、湖北省自然科學(xué)基金面上項(xiàng)目，2015CFB491、龍血竭治療自身免疫疾病的機(jī)制研究、2015.4～2017.4、3萬(wàn)元、已結(jié)題、主持。

10、廣東省科技廳產(chǎn)學(xué)研結(jié)合項(xiàng)目，010B090400047、嵌入式無(wú)線(xiàn)網(wǎng)絡(luò)在ICU臨床信息系統(tǒng)的應(yīng)用、2010/10-2013/06、30萬(wàn)元、已結(jié)題、主持。

11、國(guó)家自然科學(xué)青年基金項(xiàng)目，30900239、BmαTX14多肽與通道β亞基協(xié)同調(diào)節(jié)鈉通道功能的機(jī)制研究、2010/01-2012/12、20萬(wàn)元、已結(jié)題、主持。

二、發(fā)表的代表性研究論文：

[1]Zhou YS, Tao HB, Lv SS, Liang KQ, Shi WY, Liu KY, Li YY, Chen LY, Zhou L, Yin SJ*, Zhao QR. Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice. Acta Pharmacol Sin. 2024 Oct;45(10):2045-2060.（SCI1區(qū)top，IF8.2，*通訊作者）

[2]Zou Y, Zhao Q, Zhang X, Yu H, Zhou Y, Li Z, Xiao M, Xiang Q, Zhang L, Shi W, Tao H, Chen L, Han B, Yin S*. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats. Front Immunol. 2023 Apr 24;14:1094649. doi: 10.3389/fimmu.2023.1094649. PMID: 37168850; PMCID: PMC10165104.（SCI2區(qū)，IF5.7，*通訊作者）

[3]Zhao Q, Zhang X, Long S, Wang S, Yu H, Zhou Y, Li Y, Xue L, Hu Y, Yin S*. Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel. Mol Pharmacol. 2023 Oct;104(4):133-143. doi: 10.1124/molpharm.122.000658. Epub 2023 Jul 7. PMID: 37419692.（SCI2區(qū)，IF4.05，*通訊作者）

[4] Qiang Li , Peng Liu, Chen Wu , Lijie Bai , Zhongyun Zhang, Zilu Bao , Min Zou, Zhaoxiang Ren, Lin Yuan, Maochuan Liao, Zhou Lan, Shijin Yin*, Lvyi Chen* . Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia. J Ethnopharmacol. 2022, 298:115679. （SCI2區(qū)top，IF5.195，*通訊作者）

[5] Zhang X, Zhao Q, Yang F, Lan Z, Li Y, Xiao M, Yu H, Li Z, Zhou Y, Wu Y, Cao Z, Yin S*. Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58. Mol Pharmacol. 2022,102(3):150-160. （SCI2區(qū)，IF4.05，*通訊作者）

[6] Shujuan Shi, Qianru Zhao , Caihua Ke, Siru Long , Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin*. Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels. Frontiers in Pharmacology, 2021, 12:685092.（SCI2區(qū)top，IF5.81，*通訊作者）

[7]Yubiao Zhang, Feng Zhang, Shujuan Shi, Xinqiao Liu, Weisong Cai, Guangtao Han, Caihua Ke, Siru Long, Zhiyong Di, Shijin Yin*, Haohuan Li*. Immunosuppressive Effects of a Novel Potassium Channel Toxin Ktx-Sp2 from Scorpiops Pocoki. Cell Biosci. 2019, 9:99。（SCI3區(qū)，IF5.03，*通訊作者）

[8]Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Shijin Yin, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS, Hu H. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells.Immunity, 2018，49(1):107-119. (SCI1區(qū)，IF 19.734,).

[9]Luo J, Bavencoffe A, Yang P, Feng J, Shijin Yin, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, Hu H. Zinc inhibits TRPV1 to alleviate chemotherapy-induced neuropathic pain. J Neurosci. 2018, 38(2):474-483. (SCI1區(qū)，IF 5.988)

[10] Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Shijin Yin, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol. 2018, 141(2):608-619. (SCI1區(qū)，IF 13.06).

[11] Jing Feng, Jialie Luo, Madison R. Mack, Pu Yang, Feng Zhang, Guan Wang, Xuan Gong, Tao Cai, Zhinan Mei, Brian Kim, Shijin Yin*, Hongzhen Hu. The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice. Journal of Allergy and Clinical Immunology, 2017, 140(3):885-888. (SCI1區(qū)，IF 13.06, *通訊作者).

[12] Zou Y, Zhang F, Li Y, Wang Y, Li Y, Long Z, Shi S, Shuai L, Liu J, Di Z, Shijin Yin*. Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki. Cell & Bioscience. 2017, 7:60.（SCI3區(qū), IF 5.03, *通訊作者).

[13]Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Shijin Yin, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017, 8(1):980. (SCI1區(qū)，IF 12.124).

[14] Kim S, Barry DM, Liu XY, Shijin Yin,et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Sci Signal, 2016, 9(437):ra71.(SCI1區(qū), IF 7.359)

[15] Shijin Yin，Yanning Qiu，Zhaohui Pan，Shaobin Li，Zhiyong Di . Chaerilus pseudoconchiformus sp. nov., a new species found in Xizang, and an updated key of the chaerilid scorpions from China (Scorpiones:Chaerilidae)，ZooKeys，2015，495：41-51.（SCI）

[16] Shijin Yin，Yunfeng Zhang，Zhaohui Pan，Shaobin Li，Zhiyong Di ，Scorpiops ingens sp.nov.,found in Xizang, and an updated key of Scorpions from China(Scorpiones:Euscorpidae, Scorpiopinae)，ZooKeys，2015，495：53-61。（SCI）

[17] Kimball C, Luo J, Shijin Yin, Hu H, Dhaka A.The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Mol Pharmacol, 2015, 88(1):131-8.（SCI, IF 3.931）

[18] Shijin Yin，Qinglan Hu，Jialie Luo，Yuxin Li，Chunlan Lu，XuanChen，Hongzhen Hu. Loureirin B, an essential component of Sanguis Draxonis,inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells，Cell & Bioscience，2014，4：78。（SCI3區(qū), IF 5.03,通訊作者）

[19] Shijin,Yin, Jialie Luo, Aihua Qian, Weihua Yu, Hongzhen Hu. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol. 2014,171(6):1510-20 (SCI 2區(qū)，IF 5.06, 通訊作者)

[20] Shijin,Yin, Jialie Luo, Aihua Qian, Junhui Du, Qing Yang, Shentai Zhou, Weihua Yu, Guangwei Du, Richard B. Clark, Edgar T. Walters, Susan M. Carlton, and Hongzhen Hu. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. The Journal of Clinical Investigation, 2013, 8:1-11 (SCI1區(qū), IF 12.86)

[21] Feng J, Hu Y, Yi H, Shijin Yin, Han S, Hu J, Chen Z, Yang W, Cao Z, De Waard M, Sabatier JM, Li W, Wu Y. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013, 288(18):12544-53. (SCI 2區(qū), IF 5.7)

[22] Dai, Hui¹、Shijin Yin¹、Li, Tian、Cao, Zhijian、Ji, Yonghua、Wu, Yingliang、Li, Wenxin. Recombinant expression, purification, and characterization of scorpion toxin Bm alpha TX14. Protein Expression and Purification, 2012,82(2): 325-331.(SCI, 共同第一作者)

[23] Na Gao, Jialie Luo, Karen Uray, Aihua Qian, Shijin Yin, Guodu Wang, Xiyu Wang, Yun Xia,Jackie D. Wood, Hongzhen Hu. CaMKII Is Essential for the Function of the Enteric Nervous System. PLoS One.2012;7(8):1-10.（SCI, IF 4.351 ）

[24] Chen Z,Hu Y,Han S,Shijin Yin,He Y,Wu Y,Cao Z,Li W. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol.2011 ;25(4):244-51.(SCI)

[25] Song Han¹, Shijin Yin¹, Hong Yi. Ste′phanie Mouhat, Su Qiu, Zhijian Cao, Jean-Marc Sabatier, Yingliang Wu, and Wenxin Li. Protein-Protein Recognition Control by ModulatingElectrostaticInteractions. J Proteome Res, 2010, 9(6):3118-25（SCI 2區(qū), IF 5.684, 共同第一作者）

[26] Di Z., Cao Z, Wu Y.,Shijin Yin., Gregory D and Li W. Discovery of the centipede family Plutoniumidae(Chilopoda) in Asia: a new species of Theatops from China, and the taxonomic value of spiracle distributions in Scolopendromorpha. Zootaxa, 2010, 2667:51-63.（SCI）

[27] Liu, J., Ma, Y., Shijin Yin., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W.,. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus. Peptides, 2009, 30(4):675-80. (SCI)

[28] Shijin Yin., Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. J Proteome Res,2008, 7, 4890-4897.(SCI 2區(qū), IF 5.67)

[29] Shijin Yin; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L., Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides, 2008，29（9）: 1514-20. (SCI)

[30] Han, S¹.; Yi, H¹.; Shijin Yin¹.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem , 2008, 283, 19058-19065.(SCI 2區(qū), IF 5.7, 共同第一作者)

[31] Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Shijin Yin.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W., A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci, 2008, 33, 43-46.(SCI)

[32] Wu, W¹.; Shijin Yin¹.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W., Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides, 2007, 28, 2306-2312.（SCI, 共同第一作者）

[33] Yi, H.; Cao, Z.; Shijin Yin.; Dai, C.; Wu, Y.; Li, W., Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6, 611-620. (SCI, IF 5.67)

[34] Mao, X.; Cao, Z.; Shijin Yin.; Ma, Y.; Wu, Y.; Li, W., Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun, 2007, 360, 728-734.(SCI)

[35] Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.; Shijin Yin.; Yingliang, W.; Wenxin, L., Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides, 2006, 27, 1235-1240. (SCI）

[36] Zhijian, C.; Chao, D.; Shijin Yin.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L., Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol, 2006, 20, 1-6.(SCI)

[37] Wang, K.;Shijin Yin; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett, 2006, 28, 1767-1772.(SCI)

[38] Liu, X.; Shijin Yin.; Chen, S.; Ma, Q., Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons.Conf Proc IEEE Eng Med Biol Soc, 2005, 5, 4962-4965.(EI)

[39] Xiangming, L.; Su, C.; Shijin Yin.; Zhinan, M., Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. Sci China C Life Sci, 2004, 47, 340-348.(SCI)

三、發(fā)明專(zhuān)利

(1) 龍血竭作為制備防治自身免疫性疾病藥物中的應(yīng)用。2018.6.26，中國(guó)發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)：ZL 2014 1 0565812.0，第一發(fā)明人。

(2) 一種龍血素B的衍生物及其制備和應(yīng)用。2018.7.24,中國(guó)發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)：ZL 2017 1 0519342.8，第一發(fā)明人。

(3)一種龍血竭總黃酮的制備方法及應(yīng)用。2021.09.24，中國(guó)發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)：ZL 2019 1 0150187.6，第一發(fā)明人。

(4) 多接入點(diǎn)ZigBee網(wǎng)絡(luò)協(xié)調(diào)器。2012，中國(guó)實(shí)用新型專(zhuān)利，授權(quán)專(zhuān)利號(hào)：CN 201220123251.5，第二發(fā)明人。

(5) 基于無(wú)線(xiàn)通信的人體動(dòng)作檢測(cè)器。2012，中國(guó)實(shí)用新型專(zhuān)利，授權(quán)專(zhuān)利號(hào)：CN 201120446464.7，第二發(fā)明人。

(6) 基于ZigBee的無(wú)線(xiàn)脈搏檢測(cè)器。2012，中國(guó)實(shí)用新型專(zhuān)利，授權(quán)專(zhuān)利號(hào)：CN 201120446500.X，第二發(fā)明人。

(7) 基因工程免疫抑制多肽及制備方法和用途。2009，中國(guó)發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)：CN 101423550B，第五發(fā)明人。