姓名：馬立群
職務(wù)/職稱(chēng)：副教授（碩導(dǎo)）
通訊地址：中南民族大學(xué)生命科學(xué)學(xué)院8號(hào)樓8D301
E-mail：[email protected]
研究領(lǐng)域和方向
主要從事呼吸循環(huán)系統(tǒng)重大疾病發(fā)病機(jī)理的研究以及新藥研發(fā)。近年來(lái)重點(diǎn)研究心血管疾病與代謝性疾病的分子生物學(xué)機(jī)制，民族藥物的藥理學(xué)與毒理學(xué)。
教育背景
2002.09—2008.06華中科技大學(xué)同濟(jì)醫(yī)學(xué)院，藥理學(xué)博士
1997.09—2002.06三峽大學(xué)醫(yī)學(xué)院，臨床醫(yī)學(xué)學(xué)士
工作簡(jiǎn)歷
2014.07—至今中南民族大學(xué)生命科學(xué)學(xué)院，講師
2008.09—2014.06美國(guó)紐約大學(xué)奧本尼分校，博士后、資深研究員
近年來(lái)主持或參與的科研項(xiàng)目
1. 主持：國(guó)家自然科學(xué)基金青年項(xiàng)目（81500253），TASK-1雙孔鉀離子通道在酸中毒誘發(fā)心律失常中的病理作用，2016/01-2018/12
2. 主持：國(guó)家民委自然科學(xué)基金一般項(xiàng)目（14ZNZ021），武陵山區(qū)苦味中藥黃柏提取物抗
哮喘的作用機(jī)理研究及開(kāi)發(fā)，2015/01-2016/12
發(fā)表論文（#并列第一作者，通訊作者）
1. He Caijing#,Ma Liqun#,Muhammad Sarfaraz Iqbal, Huang Xianju*, Jun Li, Yang Guangzhogn,Awais Ihsan.Veratrilla baillonii Franchexerts anti-diabetic activity andimproves liver injury throughIRS/PI3K/AKTsignalingpathways in type 2 diabeticdb/db mice. Journal of functional foods. Accepted.
2. Qiu Junying#,Ma Liqun#, Liu Beibei, Zhang Wenjing, et al.Folium Sennae and emodin reverse airway smooth muscle contraction. Cell Biol Int.2020 Sep;44(9):1870-1880.
3. Qin Xuhui#, Wang Haixia#,Ma Liqun#, Shen Jinhua, Liu Qinghua, Xue Lu*.Knockout of the Placenta Specific 8 Gene Affects the Proliferation and Migration of Human Embryonic Kidney 293T Cell. Cell Biochemistry and Biophysics.Published on06November 2019.
4. She Yushan#,Ma Liqun#, Liu Beibei, Zhang Wenjing, et al. Semen cassiae Extract Inhibits Contraction of Airway Smooth Muscle. Frontiers in Pharmacology. Published on04December 2018.
5.Ma Liqun#, Yu You#, Li Mei, Ihsan Awais, Tong Haiying, Huang Xianju* and Gao Yue. Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line. Frontiers in Pharmacology. Published on05November 2018.
6. Ouyang Cong, Pu Yizhi, Qin Xuhui, Shen Jinhua, Liu Qinghua,Ma Liqun* and Xue Lu*. Placenta-specific 9, a putative secretory protein, induces G2/M arrest and inhibits the proliferation of human embryonic hepatic cells. BIOSCIENCE REPORTS.Published on04December 2018.
7. Huang Jun#, Ma Liqun#, Yang Yongle,Wen Nana, Zhou Wan, Cai Congli, Liu Qinghua*,Shen Jinhua*. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. Published on Nov 2017.
8.Ma Liqun,Zhang X, Zhou M,Chen H*. Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification.J Biol Chem. 2012, 287(44):37145-53.
9. Ma Liqun,Xie YP, Zhou M, Chen H*. Silent TWIK-1 Potassium Channels Conduct Monovalent Cation Currents. Biophysical Journal. 2012, 102:L34–L36.
10.Ma Liqun,Zhang X,Chen H*. TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.Sci Signal. 2011, 7; 4(176):ra37.
11.Ma Liqun,Liu C,Wang F,Xie N,Gu J,Chen JG*. Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.J Neurophysiol. 2009, 101(5):2230-8.
12. Haijun Chen#*, DongchuanZuo, JianingZhang, Min Zhou,Ma Liqun. Classification of 2-pore domain potassium channels based on rectification under quasi-physiological ionicconditions. Channels, 2014, 8(6): 503-508.
13. Zhou M#, Xu G, Xie M, Zhang X, Schools GP,Ma Liqun, Kimelberg HK, Chen HJ*. TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. Journal of Neuroscience. 2009, 29:8551-8564.
14. Chen HJ#, Kronengold J, Yan Y, Gazula VR, Brown MR,Ma Liqun, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK*. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. Journal of Neuroscience. 2009, 29:5654-5665.
承擔(dān)課程
動(dòng)物學(xué)、發(fā)育生物學(xué)、藥理學(xué)、營(yíng)養(yǎng)學(xué)等。
