姓名：付鈺
職務(wù)/職稱(chēng)：教授，博士生導(dǎo)師
通訊地址：中南民族大學(xué)生科院8-D-201室
E-mail：[email protected]
主要基于多學(xué)科交叉，開(kāi)展大健康微生物組（One Health Microbiome）研究，聚焦于利用拉曼光譜、類(lèi)器官和人工智能等技術(shù)解析腸道微生物與人體健康，環(huán)境微生物與地球健康的關(guān)聯(lián)，發(fā)掘開(kāi)發(fā)One Health產(chǎn)品。主持或參與國(guó)家自然科學(xué)基金項(xiàng)目5項(xiàng)，國(guó)家重點(diǎn)研發(fā)項(xiàng)目3項(xiàng)，中科院前沿交叉團(tuán)隊(duì)項(xiàng)目1項(xiàng)，獲英國(guó)皇家協(xié)會(huì)Newton Advanced Fellowship，第一屆“率先杯”未來(lái)技術(shù)創(chuàng)新大賽優(yōu)勝獎(jiǎng)等獎(jiǎng)項(xiàng)，入選國(guó)家“海外高層次人才引進(jìn)計(jì)劃”青年項(xiàng)目。
一、學(xué)習(xí)及工作簡(jiǎn)歷：
2025.11-至今， 中南民族大學(xué)生命科學(xué)學(xué)院教授
2013.1-2025.10 中國(guó)科學(xué)院微生物研究所研究員
2008.5-2012.12 博士后，哈佛大學(xué)醫(yī)學(xué)院生物化學(xué)與分子藥理學(xué)系
2003.09-2008.05，博士，加拿大薩斯喀徹溫大學(xué)醫(yī)學(xué)院微生物與免疫學(xué)系
2000.09-2003.08，碩士，加拿大薩斯喀徹溫大學(xué)醫(yī)學(xué)院微生物與免疫學(xué)系
1999.09-2000.08，瑞士諾華制藥公司Friedrich Miesche Institute研究助理
1997.09-1999.08，中國(guó)科學(xué)院遺傳與發(fā)育研究所研實(shí)員
1994.09-1997.08 碩士，中國(guó)科學(xué)院遺傳與發(fā)育研究所
1990.09-1994.08 本科，湖北大學(xué)生命科學(xué)系
二、近五年主持或參與的主要科研項(xiàng)目
1. 新發(fā)突發(fā)與重大傳染病防控國(guó)家科技重大專(zhuān)項(xiàng)，2025ZD01900100，千萬(wàn)級(jí)國(guó)家未知病原微生物樣本保藏庫(kù)構(gòu)建，2025/12-2028/11，2980萬(wàn)，在研，參與
2. 國(guó)家自然科學(xué)基金重大疫情的環(huán)境安全與次生風(fēng)險(xiǎn)防控重大項(xiàng)目，52091541，環(huán)境介質(zhì)中的病毒識(shí)別與傳播規(guī)律，400萬(wàn)，2021/01-2025/12，結(jié)項(xiàng)，參與
3. 北京市自然科學(xué)基金外籍學(xué)者項(xiàng)目，IS23089，拉曼光譜結(jié)合人工智能技術(shù)無(wú)損鑒定微生物及活體水平的微生物單細(xì)胞生理生化表征研究， 2023/10-2025/09，20萬(wàn)，結(jié)項(xiàng)，主持
4.國(guó)家重點(diǎn)研發(fā)計(jì)劃，2019YFA0905500，活性污泥人工多細(xì)胞體系構(gòu)建與應(yīng)用，2020/01-2024/12，2039萬(wàn)，結(jié)項(xiàng)，參與
5. 國(guó)家重點(diǎn)研發(fā)計(jì)劃，2021YFC2301000，難培養(yǎng)和微量病原體靶向培養(yǎng)技術(shù)研究，2021/12-2024/11，1964萬(wàn)，結(jié)項(xiàng)，參與
6. 國(guó)家自然科學(xué)基金面上項(xiàng)目，31970553，利用單分子技術(shù)解析釀酒酵母H1類(lèi)似蛋白Hho1和Hmo1的生理功能及對(duì)應(yīng)的分子機(jī)理，58萬(wàn)，2000/01-2023/12，結(jié)項(xiàng)，主持
三、代表性論文：（*通訊作者）
1.Zhang, Z., andFu, Y.V.*(2025). From spectrum to species: A new era of medical microbiology with AI-powered Raman spectroscopy.hLife3, 527–530.
2.王藝璇,張書(shū)娟,付鈺*(2025).子宮內(nèi)膜異位癥相關(guān)微生物組的研究進(jìn)展.微生物學(xué)報(bào)65, 4254–4271.
3.Wang, Y., Zhang, S., Han, S. L., Ge, X., Gao, S., Zhu, Q., Liu, Y., Hu, S., Jiang, Z., Dai, Y., Cai, L.,Fu, Y. V.*(2025). Whole-genome sequencing and comparative genomic analysis of Irpex lacteus isolated from the female reproductive tract.Microb Genom11(6):001416.
4.Liu, L., Xue, J., Song, Y., Zhan, T., Liu, Y., Song, X., Mei, L., Wang, D.,Fu, Y. V.*, Wei, Q.* (2025). "A Pilot Study on Single-Cell Raman Spectroscopy Combined with Machine Learning for Phenotypic Characterization of Staphylococcus aureus."Microorganisms13(6):1333
5.張書(shū)娟，劉曉秋，鐘宇新*，付鈺*(2025).腸道微生物與高尿酸血癥的關(guān)聯(lián)及創(chuàng)新性治療.生物工程學(xué)報(bào)41(6):2290-2309.
6.蔣子雯,王藝璇，任建，唐世倩，靳靈鴿，張宇迪，代蔭梅*，付鈺*(2024).女性上生殖道菌群與婦產(chǎn)疾病的關(guān)系：研究進(jìn)展與展望.微生物學(xué)通報(bào)51(12): 4842-4853.
7.Xue, J., Yue, H., Lu, W., Li, Y., Huang, G.*, andFu, Y.V.*(2024). Application of Raman spectroscopy and machine learning forCandida aurisidentification and characterization.Applied and Environmental Microbiology, e0102524.
8.Wang, L., Lu, W., Song, Y., Liu, S., andFu, Y.V.* (2024). Using machine learning to identify environmental factors that collectively determine microbial community structure of activated sludge.Environ Res260, 119635.
9.Huang, L., Lu, W., Yu, Y., Qiu, H., Zeng, Y., Wang, L., Liu, Y., Yan, L.,Fu, Y.V.*, and Zheng, Y.* (2024). The ammonium transporter AmtB is dispensable for the uptake of ammonium in the phototrophic diazotrophRhodopseudomonas palustris.Environmental Technology & Innovation36.
10.Ji, X., Xue, J., Shi, J., Wang, W., Zhang, X., Wang, Z., Lu, W., Liu, J.,Fu, Y.V.*, and Xu, N.* (2024). Noninvasive Raman spectroscopy for the detection of rice bacterial leaf blight and bacterial leaf streak.Talanta282.
11.Ke, W., Xie, Y., Chen, Y., Ding, H., Ye, L., Qiu, H., Li, H., Zhang, L., Chen, L., Tian, X., Shen, Z., Song, Z., Fan, X., Zong, J. F., Guo, Z., Ma, X., Xiao, M., Liao, G., Liu, C. H., Yin, W. B., Dong, Z., Yang, F., Jiang, Y. Y., Perlin, D. S., Chen, Y.,Fu, Y.V.*, and Wang, L.* (2024). Fungicide-tolerant persister formation during cryptococcal pulmonary infection.CellHost &Microbe32, 276-289 e277.
12.Lu, W., Wang, L., Liang, J., Lu, Y., Wang, J., andFu, Y.V.*(2023). Dynamically Quantifying Intracellular Elemental Sulfur and Predicting Pertinent Gene Transcription by Raman Spectroscopy in Living Cells.Analytical Chemistry95, 9769-9778.
13.Wang, M., Li, J., Wang, Y., Fu, H., Qiu, H., Li, Y., Li, M., Lu, Y., andFu, Y.V.*(2023). Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.mBio, e0099323.
14.Liu, Y., Zhang, Y., Zhao, X., Lu, W., Zhong, Y., andFu, Y.V. *(2023). Antifungal Peptide SP1 Damages Polysaccharide Capsule ofCryptococcus neoformansand Enhances Phagocytosis of Macrophages.Microbiol Spectr, e0456222.
15.Lu, W., Li, H., Qiu, H., Wang, L., Feng, J., and Fu, Y.V. (2023). Identification of pathogens and detection of antibiotic susceptibility at single-cell resolution by Raman spectroscopy combined with machine learning.Frontiers in Microbiology13, 1076965.
16.Liu, Y., Shao, Y., Wang, L., Lu, W., Li, S., Xu, D., andFu, Y.V.*(2022). Inactivation of porcine epidemic diarrhea virus with electron beam irradiation under cold chain conditions.Environ Technol Innov, 102715.
17.Zhang, Y., Zhou, L., Liu, Y., Zhao, X., Lian, X., Zhang, J., Zhao, D., Wang, Y., Zhong, J., Wang, J., Wang, H., Wang, L.*,Fu, Y.V.*(2022). A Peptide from Budding Yeast GAPDH Serves as a Promising Antifungal againstCryptococcus neoformans.Microbiol Spectr10, e0082621.
18.Zhao, X., Lian, X., Liu, Y., Zhou, L., Wu, B., andFu, Y.V.*(2022). A Peptide Derived from GAPDH Enhances Resistance to DNA Damage inSaccharomyces cerevisiaeCells.Applied and Environmental Microbiology88, e0219421.
19.盧維來(lái),許添順,湯暉,蔣靖坤,付鈺*(2022).微生物氣溶膠檢測(cè)技術(shù)的研究進(jìn)展.微生物學(xué)報(bào)62, 1345-1361.
20.Yu, S., Li, X., Lu, W., Li, H.,Fu, Y.V.*, and Liu, F.* (2021). Analysis of Raman Spectra by Using Deep Learning Methods in the Identification of Marine Pathogens.Analytical Chemistry93, 11089-11098.
21.Wang, Z., Liu, Y., Lu, W.,Fu, Y.V.*, and Zhou, Z.* (2021). Blood identification at the single-cell level based on a combination of laser tweezers Raman spectroscopy and machine learning.Biomed Opt Express12, 7568-7581.
22.Wang, Y., andFu, Y.V.*(2021). Yeast Nucleoplasmic Extracts and an Application to Visualize Chromatin Assembly on Single Molecules of DNA.Methods in Molecular Biology2196, 199-209.
23.Wang, Q.,Fu, Y.V.*, and Xiao, W.* (2021). Scarless Genomic Protein Labeling inSaccharomyces cerevisiae.Methods in Molecular Biology2196, 63-75.
24.Zhang, Z., Zhan, Z., Wang, B., Chen, Y., Chen, X., Wan, C.,Fu, Y.*, and Huang, L*. (2020). Archaeal Chromatin Proteins Cren7 and Sul7d Compact DNA by Bending and Bridging.mBio11.
25.Yu, S., Li, H., Li, X.,Fu, Y.V.*, and Liu, F.* (2020). Classification of pathogens by Raman spectroscopy combined with generative adversarial networks.Sci Total Environ726, 138477.
26.Lu, W., Chen, X., Wang, L., Li, H., andFu, Y.V.*(2020). Combination of an Artificial Intelligence Approach and Laser Tweezers Raman Spectroscopy for Microbial Identification.Analytical Chemistry92, 6288-6296.
27.周利艷,付鈺*(2019).一種制備新生隱球菌單細(xì)胞的方法.微生物學(xué)報(bào)59, 326-333.
28.Wang, Y., Zhang, K., Li, H., Xu, X., Xue, H., Wang, P., andFu, Y.V.*(2019). Fine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast.Sci Rep9, 12538.
29.Chen, Y., Zhan, Z., Zhang, H., Bi, L., Zhang, X.E.*, andFu, Y.V.*(2019). Kinetic analysis of DNA compaction by mycobacterial integration host factor at the single-molecule level.Tuberculosis119, 101862.
30.Xue, H., Zhan, Z., Zhang, K., andFu, Y.V.*(2018). Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified lambda DNA at the Single Molecule Level.Journal ofVisualizedExperimentse57967.
31.Fan, Q., Xu, X., Zhao, X., Wang, Q., Xiao, W., Guo, Y., andFu, Y.V.*(2018). Rad5 coordinates translesion DNA synthesis pathway by recognizing specific DNA structures inSaccharomyces cerevisiae.Curr Genet64, 889-899.
32.Xue, H., Bei, Y., Zhan, Z., Chen, X., Xu, X., andFu, Y.V.*(2017). Utilizing Biotinylated Proteins Expressed in Yeast to Visualize DNA–Protein Interactions at the Single-Molecule Level.Frontiers in Microbiology8.
33.Zhao De, Chen, X., Li, K., andFu, Y.V.*(2017). The application of thermophilic DNA primase TtDnaG2 to DNA amplification.Sci Rep7, 12809.
34.Zhao, X., Liu, X., Xu, X., andFu, Y.V.*(2017). Microbe social skill: the cell-to-cell communication between microorganisms.Science Bulletin62, 516-524.
35.Wang, Q., Xue, H., Li, S., Chen, Y., Tian, X., Xu, X., Xiao, W., andFu, Y.V.*(2017). A method for labeling proteins with tags at the native genomic loci in budding yeast.PloS one12, e0176184.
36.Fan, Q., andFu, Y.*(2017). Telomere and centromere—DNA tandem arrays on the chromosome.Chinese Science Bulletin62, 3245-3255.
37.Chen, X., Zhao, E., andFu, Y.V.*(2017). Using single-molecule approach to visualize the nucleosome assembly in yeast nucleoplasmic extracts.Science Bulletin62, 399-404.
38.Zhan, Z., Xu, X., andFu, Y.V.*(2016). Single cell tells the developmental story.Science Bulletin61, 1355-1357.
39.許鑫,付鈺*(2015).解析DNA損傷應(yīng)答之路.科學(xué)通報(bào)60, 3158-3160.
40.Xue, H., Xu, X. andFu, Y.V.*(2015) New insights in pre-replication complex formation with single-molecule visualization.Science Bulletin60(12):1133-1135
41.Fu YV, Yardimci H, Long DT, Ho TV, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Sch?rer OD, Walter JC* (2011) Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.Cell146(6): 931-941
42.Fu YVand Walter JC* (2010) DNA replication: metazoan Sld3 steps forward.Current Biology20(12): 515-517
43.Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D and Xiao W* (2008) Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.Cell133(4):601-611
四、授權(quán)專(zhuān)利
（1）付鈺，王琳淇，盧維來(lái)，仇昊寧，謝語(yǔ)嫣，一種快速無(wú)損檢測(cè)細(xì)胞中麥角硫因的方法，2025.07.22，中國(guó)，ZL 202310057609.1
（2）付鈺，趙德，一種利用嗜熱引發(fā)酶擴(kuò)增DNA的方法，2021.09.21，中國(guó)，ZL 201710153877.8
（3） 付鈺，李焓菲，盧維來(lái)，用于顯微拉曼光譜檢測(cè)好氧或兼性厭氧病原微生物的液體樣品池，2021.05.04，中國(guó)，ZL 202010198979.3
（4） 付鈺，許添順，盧維來(lái)，王璐，李焓菲，一種基于旋轉(zhuǎn)液腔的生物氣溶膠收集方法，2020.11.27，中國(guó)，ZL 201910869997.7
（5）付鈺，連憲強(qiáng)，周利艷，抗真菌肽及其用途，2020.04.21，中國(guó)，ZL 201710188194.6
五、軟件著作權(quán)：
1. 病原體拉曼識(shí)別與表征軟件，2023.05.16, 登記號(hào)：2023SR0919162
2. 一維拉曼數(shù)據(jù)的二維圖像轉(zhuǎn)換軟件，2021.08.16，登記號(hào)：2021SR1524571
六、教學(xué)活動(dòng)
（1）主講課程：中國(guó)科學(xué)院大學(xué)研究生課程《微生物學(xué)前沿》
實(shí)驗(yàn)室秉承創(chuàng)新，嚴(yán)謹(jǐn)，精進(jìn)，協(xié)作的科學(xué)精神，打造敢為人先，求真務(wù)實(shí)，和衷共濟(jì)，篤行致遠(yuǎn)的團(tuán)隊(duì)文化，熱忱歡迎有志于科研的同學(xué)報(bào)考本團(tuán)隊(duì)的博士和碩士研究生，讓我們攜手開(kāi)啟一段有趣、有用、有苦、有樂(lè)、自勉、自強(qiáng)、自信、自豪的人生之旅！
